Triethylamine → HCID 69214597, compound

Participants

Reaction Steps

A solution containing 3-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,5-a]pyridine-6-carboxylic acid (58 mg, 0.18 mmol), 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide (52 mg, 0.27 mmol), 1-hydroxybenzotriazole (24 mg, 0.18 mmol), triethylamine (60 μL, 0.45 mmol) and cyclopropyl methylamine (20 mg, 0.27 mmol) in DMF (1 mL) was stirred at room temperature overnight. Purification by preparative HPLC on reversed phase (0.1% aqueous ammonia (25%) afforded the title compound (34 mg, 50%) as a light yellow solid. MS: m/e: 373.3 [M+H]+.

Provenance & Evidence