反应详情

Methyl chloroformate (6.8 ml, 88 mmol) was added over 30 minutes to a solution of 4-fluoro-2-methylphenol (10 g, 79 mmol) in 6% aqueous sodium hydroxide solution at 0° C. The mixture was stirred for 2 hours, then extracted with ethyl acetate (100 ml). The ethyl acetate extract was washed with water (100 ml) and dried (MgSO4) and the solvent removed by evaporation to give 4-fluoro-2-methylphenyl methyl carbonate (11.4 g, 78%) as an oil.

1. extractionextracted with ethyl acetate (100 ml)
2. extractionThe ethyl acetate extract
3. washwas washed with water (100 ml)
4. dry with materialdried (MgSO4)
5. customthe solvent removed by evaporation