反应详情

Combine 4-(1-Oxo-indan-5-yloxy)-benzonitrile (1.64 g, 6.58 mmol), tert-butyl alcohol (50 ml), and grounded KOH (1.85 g, 32.89 mmol) at room temperature under nitrogen atmosphere. Stir the reaction for 24 hours then concentrate under reduced pressure. Add Ethyl acetate to the reaction mixture and wash with brine. Dry the organic layer over Na2SO4. A yellow-orange solid precipitates out to afford 101.0 mg, 0.38 mmol (5.7% yield) of the title compound: No Characterization—Characterized by sequential reaction.

1. customat room temperature
2. customthe reaction for 24 hours
3. concentrationthen concentrate under reduced pressure
4. washAdd Ethyl acetate to the reaction mixture and wash with brine
5. dry with materialDry the organic layer over Na2SO4
6. customA yellow-orange solid precipitates out