HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chlorophenethylamine → 6-{1-[2-(3-Chloro-phenyl)-ethylamino]-indan-5-yloxy}-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chlorophenethylamine | HCID 139381 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 6-(1-Oxo-indan-5-yloxy)-nicotinamide | HCID 59750639 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Product | 6-{1-[2-(3-Chloro-phenyl)-ethylamino]-indan-5-yloxy}-nicotinamide | HCID 11384257 | 60.3% |
Reaction Steps
Using a method similar to Example 1, using 6-(1-oxo-indan-5-yloxy)-nicotinamide (Intermediate 4, 805 mg, 3.00 mmol), 2-(3-chlorophenyl)ethylamine (560 mg, 3.60 mmol), Ti(iPrO)4 (1.70 g, 6.00 mmol), TiCl4 (1.0M/DCM, 6.00 ml, 6.00 mmol), and NaBH3CN (377 mg, 6.00 mmol) gives the title compound (738 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07399774B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-82990ce0e37f4829923aab8e92e2ef30 |
| Source note | uspto-grants-2008_07 |