Methyl 2-(3-hydroxycyclohexyloxymethyl)-6-methylbenzoate → 2-Methyl-6-[3-(5-methyl-2-p-tolyloxazol-4-ylmethoxy)cyclohexyloxymethyl]benzoic Acid

HRID 748028Notes

Reaction equation

HRID 748028 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([O:8][CH2:9][C:10]2[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[C:11]=2[C:12]([O:14]C)=[O:13])[CH2:3]1.[CH3:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[O:29][C:30]([CH3:35])=[C:31]([CH2:33]I)[N:32]=2)=[CH:24][CH:23]=1>>[CH3:20][C:16]1[CH:17]=[CH:18][CH:19]=[C:10]([CH2:9][O:8][CH:4]2[CH2:5][CH2:6][CH2:7][CH:2]([O:1][CH2:33][C:31]3[N:32]=[C:28]([C:25]4[CH:26]=[CH:27][C:22]([CH3:21])=[CH:23][CH:24]=4)[O:29][C:30]=3[CH3:35])[CH2:3]2)[C:11]=1[C:12]([OH:14])=[O:13]

Participants

3

Reactant 2

HCID 21980299Methyl 2-(3-hydroxycyclohexyloxymethyl)-6-methylbenzoateHCID 219803112-(4-Methylphenyl)-4-iodomethyl-5-methyloxazole

Product 1

HCID 224936382-Methyl-6-[3-(5-methyl-2-p-tolyloxazol-4-ylmethoxy)cyclohexyloxymethyl]benzoic Acid

Procedure

Using methyl 2-(3-hydroxycyclohexyloxymethyl)-6-methylbenzoate and 2-(4-methylphenyl)-4-iodomethyl-5-methyloxazole as starting materials in the procedure of Example XXXI, gave the product 70 of molecular weight 449.55 (C27H31NO5), MS(ESI): 450.36 (M+H+).

Sources & evidence

ORD record
ord-b9d1d720eccf447583e814913a2be82f
Source dataset
uspto-grants-2008_07
Patent number
US07399777B2

Reaction notes

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