Hydrochloric Acid → HCID 59751032, compound

Participants

Reaction Steps

90 mg of Methyl [2-methyl-6-[(1R,3S)-3-(5-methyl-2-(4-(2-propyl)-phenyl)-oxazol-4-ylmethoxy)-cyclohexyloxymethyl]benzoate are stirred at 90° C. in a mixture of 10 ml of tert-butanol and 1 ml of 10 N potassium hydroxide solution. The reaction is monitored by TLC. After two days, the mixture is acidified with hydrochloric acid and extracted with ethyl acetate. The combined organic phases are dried over magnesium sulfate, the solvents are removed under reduced pressure and the residue is purified by RP-HPLC. This gives 69 mg of 2-methyl-6-[(1R,3S)-3-(5-methyl-2-(4-(2-propyl)-phenyl)-oxazole-4-ylmethoxy)-cyclohexyloxymethyl]-benzoic acid as an amorphous solid. C29H35NO5 (477.61), MS(ESI): 478 (M+H+).

Provenance & Evidence