5-(1-azido-2-ethylbutyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrazole → (2-ethyl-1-{1-[(4-methylphenyl)sulfonyl]-1H-pyrazol-5-yl}butyl)amine

Participants

Reaction Steps

A mixture of 5-(1-azido-2-ethylbutyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrazole (0.260 g) and 5% Pd/C (16 mg) was stirred under an atm pressure of H2 for 15 h. The mixture was filtered through a plug of Celite and the solvent was removed in vacuo to give 0.207 g of (2-ethyl-1-{1-[(4-methylphenyl)sulfonyl]-1H-pyrazol-5-yl}butyl)amine with an impurity present. This compound was used in the next step without purification.

Provenance & Evidence