Water → HCID 11305553, compound

Participants

Reaction Steps

To 5-chloro-N-{2-ethyl-1-[1-(4-methoxybenzyl)-1H-imidazol-2-yl]butyl}thiophene-2-sulfonamide (250 mg, 0.534 mmol) in CH2Cl2 (5 mL) at −78° C. was added a solution of boron tribromide (IM in CH2Cl2, 0.80 mL, 0.80 mmol) dropwise. After 4 h, the reaction mixture was warmed to room temperature and stirred for 18 h. The reaction mixture was then slowly poured into H2O, extracted 3 times with CH2Cl2, dried over MgSO4, filtered and concentrated in vacuo. The material was purified by column chromatography (SiO2, CHCl3, then 2% MeOH/CHCl3) to yield a clear oil in 58% yield.

Provenance & Evidence