Pyridine-2-carbonitrile → 8-Methyl-2-(2-pyridyl)-4H-1,3-benzothiazine-4-one

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Reaction Steps

A mixture of 3-methyl-2-mercaptobenzoic acid (2.40 g, 14.3 mmol), 2-cyanopyridine (1.20 g, 11.9 mmol) and pyridine (50.0 ml) was refluxed for 9 hrs as described in Example 9. After cooling, the precipitated crystals were collected by filtration and recrystallized from hexane-tetrahydrofuran to give the titled compound (1.60 g, 52%).

Provenance & Evidence