HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-(4-Methoxy-2-pyridyl)-4H-1,3-benzothiazine-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzoic acid, 2-mercapto-, methyl ester | HCID 21009 | — |
| Reactant | 4-Methoxypyridine-2-carbonitrile | HCID 13415156 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(4-Methoxy-2-pyridyl)-4H-1,3-benzothiazine-4-one | HCID 59750390 | 81% |
Reaction Steps
A mixture of methyl thiosalicylate (2.0 g, 11.7 mmol), 4-methoxy-2-cyanopyridine (1.5 g, 11.1 mmol), triethylamine (2.5 ml, 17.9 mmol) and toluene (5 ml) was refluxed for 12 hrs as described in Example 1. The precipitated crystals were collected by filtration and recrystallized from hexane-chlorobenzene to give the titled compound (2.4 g, 81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07399759B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-dfcccadbec9f4f7f9eeb0b9d2fca53b0 |
| Source note | uspto-grants-2008_07 |