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Triethylamine → 2-[5-(trifluoromethyl)-2-pyridyl]-4H-1,3-benzothiazine-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Benzoic acid, 2-mercapto-, methyl ester | HCID 21009 | — |
| 反応物 | 5-(Trifluoromethyl)pyridine-2-carbonitrile | HCID 1535372 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-[5-(trifluoromethyl)-2-pyridyl]-4H-1,3-benzothiazine-4-one | HCID 59750095 | 23% |
反応手順
A mixture of methyl thiosalicylate (0.43 g, 2.6 mmol), 2-cyano-5-trifluoromethylpyridine (0.44 g, 2.6 mmol), triethylamine (0.60 ml, 3.8 mmol) and toluene (30 ml) was refluxed for 48 hrs as described in Example 1. The solvent was concentrated under reduced pressure. The residue was recrystallized from ethanol to give the titled compound (0.18 g, 23%) as crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07399759B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-39c597c224a14c209a14db298071cfd7 |
| 出典メモ | uspto-grants-2008_07 |