HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 59750346, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzoic acid, 2-mercapto-, methyl ester | HCID 21009 | — |
| Reactant | 6-[(Propan-2-yl)oxy]pyridine-3-carbonitrile | HCID 22939320 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 59750346 | HCID 59750346 | 30% |
Reaction Steps
A mixture of methyl thiosalicylate (1.85 g, 11.0 mmol), 2-isopropoxy-5-cyanopyridine (1.62 g, 10.0 mmol), triethylamine (1.80 ml, 12.9 mmol) and toluene (10 ml) was refluxed under nitrogen atmosphere for 30 hrs. The reaction mixture was concentrated. The residue was subjected to a silica gel column chromatography, eluted with ethyl acetate-hexane (2:1, v/v) and recrystallized from ethyl acetate-isopropylether to give the titled compound (0.89 g, 30%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07399759B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-2a7eada100a643ffaea076fbd18ec4d5 |
| Source note | uspto-grants-2008_07 |