tert-Butyl acrylate → HCID 22939571, compound

HRID 748166Notes

Reaction equation

HRID 748166 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][CH2:9][OH:10])=[CH:3][CH:2]=1.[C:11]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])(=[O:14])[CH:12]=[CH2:13]>CO>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][CH2:9][O:10][CH2:13][CH2:12][C:11]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 15458tert-Butyl acrylateHCID 729234-Pyridinepropanol

Product 1

HCID 22939571HCID 22939571, compoundYield 86.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Triton B (40% methanol solution, 0.5 ml) was concentrated under reduced pressure, and 4-pyridinepropanol (10.2 g, 74.5 mmol) was added thereto. After 15 minutes, tert-butyl acrylate (9.59 g, 74.8 mmol) was added to the mixture, and the mixture was stirred at room temperature for 6 hrs. The reaction mixture was subjected to a silica gel column chromatography, eluted with hexane-ethyl acetate (1:1, v/v) to give the titled compound (17.1 g, 86%).

Workup

  1. additionwas added
  2. washeluted with hexane-ethyl acetate (1:1

Sources & evidence

ORD record
ord-e580d02dca2e4ffda912b27ff115ee75
Source dataset
uspto-grants-2008_07
Patent number
US07399759B2

Reaction notes

Loading…