HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-(6-Methyl-2-pyridyl)-4H-1,3-benzothiazine-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzoic acid, 2-mercapto-, methyl ester | HCID 21009 | — |
| Reactant | 6-Methylpyridine-2-carbonitrile | HCID 74182 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(6-Methyl-2-pyridyl)-4H-1,3-benzothiazine-4-one | HCID 22939586 | 55% |
Reaction Steps
A mixture of methyl thiosalicylate (0.85 g, 5.1 mmol), 2-cyano-6-methylpyridine (0.60 g, 5.1 mmol), triethylamine (1.10 ml, 7.9 mmol) and toluene (1.1 ml) was refluxed for 9 hrs. After cooling, the precipitated crystals were collected by filtration and recrystallized from ethanol to give the titled compound (0.71 g, 55%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07399759B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-ebd51ba179cd475b811a4a697a811f66 |
| Source note | uspto-grants-2008_07 |