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Triethylamine → 2-(4-tert-Butoxycarbonylamino-2-pyridyl)-4H-1,3-benzothiazine-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Benzoic acid, 2-mercapto-, methyl ester | HCID 21009 | — |
| 反応物 | tert-Butyl (2-cyanopyridin-4-yl)carbamate | HCID 22939607 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(4-tert-Butoxycarbonylamino-2-pyridyl)-4H-1,3-benzothiazine-4-one | HCID 22939388 | 49% |
反応手順
A mixture of methyl thiosalicylate (0.61 g, 3.7 mmol), 4-tert-butoxycarbonylamino-2-cyanopyridine (0.80 g, 3.7 mmol), triethylamine (0.80 ml, 5.7 mmol) and toluene (2.0 ml) was refluxed for 9 hrs. After cooling, the precipitated crystals were collected by filtration and dried to give the titled compound (0.60 g, 49%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07399759B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-a69a8eff33154d8ba87bd21a3bad250a |
| 出典メモ | uspto-grants-2008_07 |