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Triethylamine → 2-(6-Benzylthio-2-pyridyl)-4H-1,3-benzothiazine-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Benzoic acid, 2-mercapto-, methyl ester | HCID 21009 | — |
| 反応物 | 6-(Benzylthio)picolinonitrile | HCID 22939622 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(6-Benzylthio-2-pyridyl)-4H-1,3-benzothiazine-4-one | HCID 22939593 | 44% |
反応手順
2-Benzylthio-6-cyanopyridine (1.63 g, 7.22 mmol) and methyl thiosalicylate (1.21 g, 7.22 mmol) were dissolved in toluene (30 ml), and triethylamine (1.52 ml, 10.8 mmol) was added thereto. The reaction mixture was refluxed for 48 hrs. The solvent was evaporated and the residue was recrystallized from ethanol to give the titled compound (1.03 g, 44%) as white crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07399759B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-a7c6ab6062824890aa342d84b6044cc4 |
| 出典メモ | uspto-grants-2008_07 |