Sulfuric Acid → HCID 86628985, compound

HRID 748362Notes

Reaction equation

HRID 748362 reaction equation
[C:1]([C:3]1[N:8]=[C:7]([CH2:9][C:10]([OH:12])=[S:11])[CH:6]=[CH:5][CH:4]=1)#[N:2].S(=O)(=O)(O)O.ClCCl.[CH2:21]=[C:22]([CH3:24])[CH3:23]>O>[C:1]([C:3]1[N:8]=[C:7]([CH2:9][C:10]([O:12][C:22]([CH3:24])([CH3:23])[CH3:21])=[S:11])[CH:6]=[CH:5][CH:4]=1)#[N:2]

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 6344DichloromethaneHCID 8255IsobutyleneHCID 178509753HCID 178509753, compound

Product 1

HCID 86628985HCID 86628985, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

(6-Cyano-2-pyridyl)thioacetic acid (4.56 g, 23.5 mmol) and concentrated sulfuric acid (1 ml) were added to dichloromethane (300 ml), and isobutene was added thereto. The reaction mixture was sealed and stirred at room temperature for 18 hrs. Water was added to the reaction mixture. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate. The solvent was evaporated to give the titled compound (5.77 g, 98%) as a pale yellow oil.

Workup

  1. additionwas added
  2. customThe reaction mixture was sealed
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated

Sources & evidence

ORD record
ord-e040ffce7521470ebfba3624b62eeade
Source dataset
uspto-grants-2008_07
Patent number
US07399759B2

Reaction notes

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