反应详情

tert-Butyl 3-(4-pyridyl)propionate (0.58 g, 2.8 mmol) was dissolved in ethyl acetate (4 ml), and 3-chloroperbenzoic acid (ca. 77%, 0.65 g, 2.9 mmol) was added thereto. The reaction mixture was stirred at room temperature for 18 hrs and subjected to a silica gel (35 g) column chromatography. The fractions eluted with ethyl acetate-ethanol (3:1, v/v) were collected and concentrated. The residue was dissolved in nitroethane (4 ml), and trimethylsilyl cyanide (0.50 g, 5.1 mmol) and N,N-dimethylcarbamoyl chloride (0.54 g, 5.1 mmol) were added thereto. The reaction mixture was stirred at room temperature for 16 hrs and combined with ethyl acetate and water. The organic layer was successively washed with saturated aqueous sodium hydrogen carbonate solution and saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the residue was subjected to a silica gel (30 g) column chromatography. The fractions eluted with hexane-ethyl acetate (4:1, v/v) were collected and concentrated to give the titled compound (0.52 g, 79%).

1. washThe fractions eluted with ethyl acetate-ethanol (3:1
2. customv/v) were collected
3. concentrationconcentrated
4. dissolutionThe residue was dissolved in nitroethane (4 ml)
5. stirringThe reaction mixture was stirred at room temperature for 16 hrs
6. washThe organic layer was successively washed with saturated aqueous sodium hydrogen carbonate solution and saturated brine
7. dry with materialdried over anhydrous magnesium sulfate
8. customThe solvent was evaporated
9. washThe fractions eluted with hexane-ethyl acetate (4:1
10. customv/v) were collected
11. concentrationconcentrated