2,6-Dimethylbenzoic acid → HCID 44447731, compound

HRID 748478Notes

Reaction equation

[CH3:1][C:2]1([N:8]2[CH2:13][CH2:12][CH:11]([N:14]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:15]3[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=3)[CH2:10][CH2:9]2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[CH3:27][C:28]1[CH:36]=[CH:35][CH:34]=[C:33]([CH3:37])[C:29]=1[C:30](O)=[O:31].C1(NC2CCN(C(OC(C)(C)C)=O)CC2)C=CC=CC=1.Cl.BrC1C=CN=CC=1>>[CH3:27][C:28]1[CH:36]=[CH:35][CH:34]=[C:33]([CH3:37])[C:29]=1[C:30]([N:5]1[CH2:4][CH2:3][C:2]([CH3:1])([N:8]2[CH2:13][CH2:12][CH:11]([N:14]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:15]3[CH:16]=[CH:17][N:18]=[CH:19][CH:20]=3)[CH2:10][CH2:9]2)[CH2:7][CH2:6]1)=[O:31]

Participants

Reactant 4

HCID 124392,6-Dimethylbenzoic acid

HCID 881004-Bromopyridinium chloride

HCID 14915021-Boc-4-AP

HCID 69025090HCID 69025090, compound2×

Product 1

HCID 44447731HCID 44447731, compound

Procedure

It is prepared from (4′-methyl-[1,4′]bipiperidinyl-4-yl)-phenyl-pyridin-4-yl-amine and 2,6-dimethyl-benzoic acid using a procedure as described in above Example 1. MS/ESI 483 [M+H]+. (4′-Methyl-[1,4′]bipiperidinyl-4-yl)-phenyl-pyridin-4-yl-amine used as starting material can be prepared from tert-butyl 4-phenylaminopiperidine-1-carboxylate and 4-bromopyridine hydrochloride using procedures as described in Example 1a-1d of PCT/EP02/03871. MS/ESI 351 [M+H]+

Sources & evidence

ORD record: ord-6ab587ca192b41b3ac91bc4d849d5369
Source dataset: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07399771B2

Reaction notes

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