HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloroaniline → {4-[(4-Chloro-phenyl)-(2-methyl-thiazol-4-ylmethyl)-amino]-4'-methyl-[1,4']bipiperidinyl-1'-yl}-(2,4-dimethyl-pyridin-3-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloroaniline | HCID 7812 | — |
| Reactant | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| Reactant | 4-(Chloromethyl)-2-methyl-1,3-thiazole | HCID 736341 | — |
| Reactant | 2,4-Dimethyl-3-pyridinecarboxylic acid | HCID 1512561 | — |
| Reactant | (4'-Methyl-[1,4']bipiperidinyl-4-yl)-phenyl-pyridin-3-yl-amine | HCID 69024358 | — |
| Reactant | 4'-Methyl-[1,4']bipiperidinyl-4-yl-(2-methyl-thiazol-4-ylmethyl)-amine | HCID 86602462 | — |
| Product | {4-[(4-Chloro-phenyl)-(2-methyl-thiazol-4-ylmethyl)-amino]-4'-methyl-[1,4']bipiperidinyl-1'-yl}-(2,4-dimethyl-pyridin-3-yl)-methanone | HCID 59750630 | — |
Reaction Steps
It is prepared from (chloro-phenyl)-(4′-methyl-[1,4′]bipiperidinyl-4-yl-(2-methyl-thiazol-4-ylmethyl)-amine and 2,4-dimethyl-nicotinic acid using a procedure as described in Example 1 of PCT/EP02/03871. MS-ESI 552 [M+H]+. (4′-Methyl-[1,4′]bipiperidinyl-4-yl)-phenyl-pyridin-3-yl-amine used as starting material can be prepared from 4-chloro-phenylamine, 4-oxo-piperidine-1-carboxylic acid tert-butyl ester and 4-chloromethyl-2-methyl-thiazole using procedures as described in Example 51e, 52, 1b, 1c and 1d of PCT/EP02/03871. MS/ESI 419 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07399771B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-99ac31a605254886a0a947ebe4d4a0fa |
| Source note | uspto-grants-2008_07 |