4-(Chloromethyl)-2-methyl-1,3-thiazole → HCID 59750622, compound

Participants

Reaction Steps

It is prepared from (2,6-dimethyl-phenyl)-[4′-methyl-4-(1-methyl-1H-indol-7-ylamino)-[1,4′]bipiperidinyl-1′-yl]-methanone and 4-chloromethyl-2-methyl-thiazole using a procedure as described for Example 52 of PCT/EP02/03871. MS/ESI 570 [M+H]+. (2,6-Dimethyl-phenyl)-[4′-methyl-4-(1-methyl-1H-indol-7-ylamino)-[1,4′]bipiperidinyl-1′-yl]-methanone used as starting material may be prepared from 1′-(2,6-dimethyl-benzoyl)-4′-methyl-[1,4′]bipiperidinyl-4-one and 1-methyl-1H-indol-7-ylamine using a procedure as described in Example 51e of PCT/EP02/03871. MS/ESI 459 [M+H]+. 1′-(2,6-Dimethyl-benzoyl)-4′-methyl-[1,4′]bipiperidinyl-4-one may be prepared using a procedure as described in Example 51a-d of PCT/EP02/03871. MS/ESI 329 [M+H]+.

Provenance & Evidence