HCID 21336305, compound → HCID 59750626, compound

HRID 748483Notes

Reaction equation

[CH3:1][C:2]1([N:8]2[CH2:13][CH2:12][CH:11]([N:14]([CH2:21][C:22]3[N:23]=[C:24]([CH3:27])[S:25][CH:26]=3)[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:10][CH2:9]2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[CH3:28][C:29]1[C:34]([C:35](O)=[O:36])=[C:33]([CH3:38])[N:32]=[C:31]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[N:30]=1>>[CH3:38][C:33]1[C:34]([C:35]([N:5]2[CH2:6][CH2:7][C:2]([CH3:1])([N:8]3[CH2:9][CH2:10][CH:11]([N:14]([CH2:21][C:22]4[N:23]=[C:24]([CH3:27])[S:25][CH:26]=4)[C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[CH2:12][CH2:13]3)[CH2:3][CH2:4]2)=[O:36])=[C:29]([CH3:28])[N:30]=[C:31]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[N:32]=1

Participants

Reactant 2

HCID 21336305HCID 21336305, compound

HCID 68810382HCID 68810382, compound2×

Product 1

HCID 59750626HCID 59750626, compound

Procedure

It is prepared from (4′-methyl-[1,4′]bipiperidinyl-4-yl)-(2-methyl-thiazol-4-ylmethyl)-phenyl-amine and 4,6-dimethyl-2-phenyl-pyrimidine-5-carboxylic acid using a procedure as described for Example 1 of PCT/EP02/03871. MS/ESI 595 [M+H]+. (4′-Methyl-[1,4′]bipiperidinyl-4-yl)-(2-methyl-thiazol-4-ylmethyl)-phenyl-amine used as a starting material may be prepared using procedures described in example 83 of PCT/EP02/03871. MS/ESI 385 [M+H]+

Workup

custommay be prepared

Sources & evidence

ORD record: ord-24db486c001e401e9ac9f621399a2d4e
Source dataset: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07399771B2

Reaction notes

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