HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium methanolate methanol → HCID 86658286, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium methanolate methanol | HCID 23694274 | — |
| Reactant | 4-(Cholestan-3beta-yl-oxymethyl)[1,2,3]triazol-1-yl 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl-(1->4)-2,3,6-tri-O-acetyl-beta-D-glucopyranoside | HCID 86658287 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | HCID 86658286 | HCID 86658286 | — |
Reaction Steps
Dry N-glycoside 91 (100 mg, 0.092 mmol) was dissolved in anhydrous CH3OH and a solution of NaOMe/CH3OH (11M, 30 μL) was added dropwise to the mixture at 0° C. under argon. The solution was allowed to stir at RT overnight. After monitoring by TLC, additional anhydrous CH3OH (2 mL) and NaOMe/CH3OH (11M, 50 μL) was added and the reaction mixture found to be pH 11. Upon completion, the reaction was neutralised to pH 6 by the addition of Dowex H+ ion-exchange resin, and the resulting suspension dissolved in CHCl3/CH3OH (1:1) at 40° C. The solution was filtered, concentrated and dried over P2O5 to yield the crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828952B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-628078b4457d44d2b5c4780004a6c8d0 |
| Source note | uspto-grants-2014_09 |