1-Pyrrolidineethanamine → HCID 11162077, compound

Participants

Reaction Steps

The title compound was prepared as described for Example 3 using 2-pyrrolidin-1-yl-ethylamine and 6-chloropyridine-3-sulfonyl chloride (described in: Naegeli, C. et al. Helv. Chim. Actal. 1938, 21, 746-1750). Purification on a silica gel column using ethyl acetate/triethylamine, (9:1), as the eluent gave the title compound. Yield: 58%: 1H NMR (CDCl3, 400 MHz) δ 8.79 (d, J=2Hz, 1 H), 8.05 (dd, J=8, 3Hz, 1 H), 7.42 (d, J=9 Hz, 1 H), 3.00 (app. t, J=6 Hz, 2 H), 2.50 (app. t, J=6 Hz, 2 H), 2.33 (m, 4 H), 1.67 (m, 4 H); 13C NMR (CDCl3, 100 MHz) δ 155.7, 148.8, 137.8, 136.1, 125.0, 54.1, 53.9, 41.6, 23.9; MS (TSP) m/z 290 (M++1).

Provenance & Evidence