2-Oxo-2,3-dihydro-1H-indole-5-carbonitrile → HCID 136342126, compound

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The title compound was prepared as described for Example 82 using 5-cyanooxindole and 1-[(6-chloropyridin-3-yl)sulfonyl]-4-(3-methylbutyl)piperazine. Yield: 5% of the title compound as a yellow solid: 1H NMR (DMSO-d6, 400 MHz) δ 11.15 (br s, 1 H), 10.63 (br s, 1 H), 8.57 (s, 1 H), 8.02 (s, 1 H), 7.94-7.81 (m, 1 H), 7.73 (d, J=9 Hz, 1 H), 7.41 (d, J=8 Hz, 1 H), 7.05 (d, J=8 Hz, 1 H), 3.82-3.67 (m, 2 H), 3.62-3.34 (m, 2 H), 3.20-2.92 (m, 6 H), 1.64-1.46 (m, 3 H), 0.86 (d, J=6 Hz, 6 H); MS (ES) m/z 454 (M++1).

Provenance & Evidence