2-Oxo-2,3-dihydro-1H-indole-5-carbonitrile → HCID 136342128, compound

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Reaction Steps

The title compound was prepared as described for Example 82 using 5-cyanooxindole and 1-[(6-chloropyridin-3-yl)sulfonyl]-4-isopropylpiperazine. Yield: 30% of the title compound as a yellow solid; 1H NMR (DMSO-d6, 400 MHz) δ 11.56 (br s, 1 H), 10.68 (br s, 1 H), 8.57 (br s, 1 H), 8.02 (s, 1 H), 7.93-7.81 (m, 1 H), 7.74 (dd, J=9, 2 Hz, 1 H), 7.42 (dd, J=8, 1 Hz, 1 H), 7.06 (d, J=8 Hz, 1 H) 3.82-3.71 (m, 2 H), 3.58-3.31 (m, 3 H), 3.24-1.82 (m, 4 H), 1.24 (d, J=7 Hz, 6 H); MS (ES) m/z 304 (M++1).

Provenance & Evidence