4-(6-chloro-pyridine-3-sulfonyl)-morpholine → HCID 136342138, compound

HRID 748550Notes

Reaction equation

HRID 748550 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[C:17]([C:19]1[CH:20]=[C:21]2[C:25](=[CH:26][CH:27]=1)[NH:24][C:23](=[O:28])[CH2:22]2)#[N:18]>>[OH:28][C:23]1[NH:24][C:25]2[C:21]([C:22]=1[C:2]1[CH:3]=[CH:4][C:5]([S:8]([N:11]3[CH2:16][CH2:15][O:14][CH2:13][CH2:12]3)(=[O:10])=[O:9])=[CH:6][N:7]=1)=[CH:20][C:19]([C:17]#[N:18])=[CH:27][CH:26]=2

Participants

3

Reactant 2

HCID 2741474-(6-chloro-pyridine-3-sulfonyl)-morpholineHCID 27733462-Oxo-2,3-dihydro-1H-indole-5-carbonitrile

Product 1

HCID 136342138HCID 136342138, compound

Procedure

The title compound was prepared as described for Example 101 using 4-[(6-chloropyridin-3-yl)sulfonyl]morpholine and 5-cyanooxindole. The reaction mixture was quenched with water and the solvents were evaporated in vacuo. Water was added and the mixture was filtered. The solid material was washed with water, methanol, ethyl acetate and diethyl ether to give the title compound. Yield: 44%: MS (ES) m/z 385 (M++1).

Workup

  1. customThe title compound was prepared
  2. customThe reaction mixture was quenched with water
  3. customthe solvents were evaporated in vacuo
  4. additionWater was added
  5. filtrationthe mixture was filtered
  6. washThe solid material was washed with water, methanol, ethyl acetate and diethyl ether

Sources & evidence

ORD record
ord-1fde4bcd212b4803beb3d354148dcbaa
Source dataset
uspto-grants-2008_07
Patent number
US07399780B2

Reaction notes

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