HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 3-(Hydroxymethyl)-1H-pyrrole-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Maleimide | HCID 10935 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Product | 3-(Hydroxymethyl)-1H-pyrrole-2,5-dione | HCID 21981751 | — |
Reaction Steps
When maleimide (manufactured by Aldrich Chemical Co., Inc.) of 24 parts, 35% HCOH (manufactured by Wako Pure Chemical Industries, Ltd.) of 21 parts, and an aqueous 5% NaOH solution of 0.7 parts are mixed and reacted at 40° C. for 2 hours to precipitate hydroxymethylmaleimide in the form of a white crystal. The produced hydroxymethylmaleimide is filtered in reduced pressure and vacuum dried at room temperature. The crude crystal of hydroxymethylmaleimide obtained in such a manner is recrystallized in ethyl acetate to obtain hydroxymethylmaleimide of 22 parts.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07399816B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-afbf946514684c829070bdb0b279cc09 |
| Source note | uspto-grants-2008_07 |