Hydrochloric Acid → HCID 68982736, compound

Participants

Reaction Steps

To 30 g of 2-(tert-butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-5-nitro-phenoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester (5) in 240 mL MeOH at 0° C. was added 2.6 mL of 1N HCl, dropwise. The reaction mixture was warmed up to room temperature and stirred for an additional 4 hours. After cooling to 0° C., to the reaction mixture was added 5 g of NaHCO3 and the mixture was extracted with EtOAc. The combined organic layers were dried over MgSO4, filtered and concentrated to afford 22.7 g of 4-(3-fluoro-5-nitro-phenoxy)-2-hydroxymethyl-pyrrolidine-1-carboxylic acid tertbutyl ester (6).

Provenance & Evidence