HCID 59751465, compound → Ammonia methanol

Participants

Reaction Steps

A solution of quinolin-4-yl-(1-trityl-1H-imidazol-4-yl)-methanone (Intermediate G2) (13.1 mmol) in THF (100 mL) at 0° C. was treated with MeMgBr (9.0 mL, 27 mmol of a 3M solution in Et2O) for 45 m. The mixture was quenched with a sat. solution of NH4Cl and water. The layers were separated and the organic layer dried over MgSO4. The suspension was filtered and evaporated to dryness. The material was purified by chromatography on SiO2 with 50% EtOAc:hexane to 5% NH3-MeOH: dichloromethane to give 1-quinolin-4-yl-1-(1-trityl-1H-imidazol-4-yl)-ethanol (Intermediate G3) 5.69 g.

Provenance & Evidence