反应详情

The 2-[1-[(4-chlorophenyl)sulfonyl]-2-methyl-5-(methylsulfinyl)pentyl]-1,4-difluorobenzene (66 mg, 0.15 mmol) obtained in Example 45 was dissolved in methylene chloride (5 ml). Under ice cooling, 3-chloroperbenzoic acid (32 mg, 0.19 mmol) was added. The resulting mixture was stirred at room temperature for 3 hours. The residue obtained by concentrating the reaction mixture under reduced pressure was purified by silica gel chromatography (methylene chloride:methanol=100:1) to yield a white solid. The resulting white solid was washed with diethyl ether/methylene chloride, whereby the title compound (52 mg, 76%) was obtained as a white powder.

1. customThe residue obtained
2. concentrationby concentrating the reaction mixture under reduced pressure
3. customwas purified by silica gel chromatography (methylene chloride:methanol=100:1)
4. customto yield a white solid
5. washThe resulting white solid was washed with diethyl ether/methylene chloride, whereby the title compound (52 mg, 76%)
6. customwas obtained as a white powder