Cyanomethylenetributylphosphorane → HCID 59750717, compound

Participants

Reaction Steps

To a toluene (3 ml) solution of 6-(1-benzyl-1H-tetrazol-5-yl)-6-[(4-chlorophenyl)sulfonyl]-1-hexanol (104 mg, 0.24 mmol) was added a toluene (2 ml) solution of cyanomethylenetri-n-butylphosphorane (128 mg, 0.48 mmol). The resulting mixture was heated under reflux for 7 hours. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. The residue was subjected to flash silica gel chromatography and the fraction obtained from the hexane:ethyl acetate=4:1 eluate was concentrated under reduced pressure. The resulting solid was washed with hexane/diethyl ether and then, collected by filtration, whereby the title compound (51 mg, 0.12 mmol, 51%) was obtained as a white solid.

Provenance & Evidence