Cyanomethylenetributylphosphorane → HCID 59750788, compound

Participants

Reaction Steps

To a toluene (3 ml) solution of 6-(2-benzyl-2H-tetrazol-5-yl)-6-[(4-chlorophenyl)sulfonyl]-1-hexanol (145 mg, 0.33 mmol) was added a toluene (3 ml) solution of cyanomethylenetri-n-butylphosphorane (179 mg, 0.67 m=ol). The resulting mixture was heated under reflux for 7 hours. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. The residue was subjected to flash silica gel chromatography and the fraction obtained from the hexane:ethyl acetate=4:1 eluate was concentrated under reduced pressure. The resulting solid was washed with hexane/diethyl ether and collected by filtration, whereby the title compound (78 mg, 0.19 mmol, 56%) was obtained as a white solid.

Provenance & Evidence