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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 74877Generated: October 26, 2026

1-Hydroxybenzotriazole → 3-((2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)piperidin-1-yl)-3-methylbutan-1-one

https://huagongshe.com/reaction/74877

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-HydroxybenzotriazoleHCID 75771—
Reactant1-Methylcyclopropanecarboxylic acidHCID 81326—
ReactantDiisopropylethylamineHCID 81531—
Reactant1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
Reactantdichloromethane N,N-dimethylformamideHCID 22350042—
Product3-((2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)piperidin-1-yl)-3-methylbutan-1-oneHCID 131731863—

Reaction Steps

1-methylcyclopropane-1-carboxylic acid, EDAC-HCl, HOBt, iPr2NEt, CH2Cl2/DMF.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08829007B2
Source datasetuspto-grants-2014_09
ORD IDord-e9bae1ef4c96459f8cd669019bf4f9a3
Source noteuspto-grants-2014_09