Methanesulfonyl chloride → 2-[1-[(4-Chlorophenyl)sulfonyl]cyclopropyl]-1,4-difluorobenzene

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Reaction Conditions

Reaction Steps

Under an argon atmosphere and at −78° C., n-butyl lithium (a 1.57M hexane solution, 600 μl, 0.942 mmol) was added to a tetrahydrofuran solution (4 ml) of the 3-[(4-chlorophenyl)sulfonyl]-3-(2,5-difluorophenyl)-1-propanol (300 mg, 0.865 mmol) obtained in Example 207. After stirring for 5 minutes, methanesulfonyl chloride (70.6 μl, 0.908 mmol) was added. The resulting solution was stirred for further 5 minutes and then, n-butyl lithium (a 1.57M hexane solution, 601 μl, 0.944 mmol) was added thereto. The temperature of the reaction mixture was elevated to room temperature, at which stirring was conducted for 18 hours. After cooling to −78° C., n-butyl lithium (a 1.57M hexane solution, 400 μl, 0.255 mmol) was added. The reaction mixture was stirred at room temperature for 3 hours. Water was added, followed by extraction with ethyl acetate. The extracts were combined, washed with brine, dried over magnesium sulfate and then, concentrated. The residue thus obtained was subjected to flash chromatography on a silica gel column, and the fraction obtained from the hexane:ethyl acetate=19:1 eluate was concentrated. The solid thus obtained was recrystallized from ethyl acetate-hexane, whereby the title compound (161 mg, 0.489 mmol, 57%) was obtained as colorless plate crystals.

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