反应详情

In dichloromethane (5 ml) was dissolved t-butyl N-[3-[(4-chlorophenyl)sulfonyl]-3-(2,5-difluorophenyl)propyl]-N-(2-hydroxyethyl)carbamate (300 mg, 0.607 mmol) and trifluoroacetic acid (0.5 ml) was added dropwise to the resulting solution under ice cooling. After stirring at room temperature for 2 hours, the reaction mixture was concentrated under reduced pressure. To the residue was added a 1N solution (5 ml) of hydrochloric acid in ethanol, followed by concentration under reduced pressure to give a white solid. The solid thus obtained was washed with diethyl ether, whereby the title compound (249 mg, 0.579 mmol, 95%) was obtained as a white powder.

1. additionwas added dropwise to the resulting solution under ice cooling
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. additionTo the residue was added a 1N solution (5 ml) of hydrochloric acid in ethanol
4. concentrationfollowed by concentration under reduced pressure
5. customto give a white solid
6. customThe solid thus obtained