Trifluoroacetic acid → HCID 67102076, compound

Participants

Reaction Steps

In dichloromethane (50 ml) was dissolved t-butyl 4-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)methyl]-1-piperidinecarboxylate (1.56 g, 3.21 mmol). Under ice cooling, trifluoroacetic acid (5.0 ml) was added dropwise to the resulting solution. After stirring at room temperature for 2 hours, the reaction mixture was concentrated under reduced pressure. Dichloromethane (10 ml) and a 1N ethanol solution (10 ml) of hydrochloric acid were added, followed by concentration under reduced pressure to give a white solid. The resulting solid was washed with diethyl ether, whereby the title compound (1.36 g, 3.12 mmol, 97%) was obtained as a white powder.

Provenance & Evidence