Lithium Hydroxide → HCID 23114798, compound

Participants

Reaction Steps

In tetrahydrofuran (5 ml) was dissolved methyl 3-[6-[(4-chlorophenylsulfonyl)-(2,5-difluorophenyl)methyl]pyridin-3-yl]propionate (92 mg, 0.20 mmol). An aqueous solution (3 ml) of lithium hydroxide (23 mg, 0.5 mmol) was added and the mixture was stirred for 2 hours. After the addition of 10% sodium bisulfate, the mixture was extracted with ethyl acetate. The extract was washed with water and brine, dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue thus obtained was crystallized from ethanol to yield the title compound (67 mg, 75%) as needle crystals.

Provenance & Evidence