Dichloromethane → HCID 23114889, compound

Participants

Reaction Steps

To a methylene chloride solution (15 ml) of the 3-[(4-chlorophenylsulfonyl)-(2,5-difluorophenyl)methyl]pyridine (162 mg, 0.427 mmol) obtained in Example 141 was added 3-chloroperbenzoic acid (81 mg, 0.47 mmol) and the mixture was stirred for 24 hours. The reaction mixture was diluted with ether (60 ml), followed by washing with a saturated aqueous solution of sodium bicarbonate, water and brine. After drying, the solution was filtered and the filtrate was concentrated under reduced pressure. The residue thus obtained was subjected to silica gel chromatography (ethyl acetate), whereby the title compound (68 mg, 40%) was obtained. The compound was crystallized from ethanol and was obtained as colorless needle crystals.

Provenance & Evidence