Trifluoroacetic acid → HCID 23114615, compound

Participants

Reaction Steps

In methylene chloride (2.0 ml) was dissolved tert-butyl 2-[N-[5-chloro-4-[(4-chlorophenylsulfonyl)-(2,5-difluorophenyl)methyl]pyridine-2-yl]-N-methylamino]ethyl-methylcarbamate (61 mg, 0.10 mmol), followed by the addition of anisole (40 μl) and trifluoroacetic acid (200 μl) at room temperature. The resulting mixture was stirred for 1 hour. The residue obtained by concentrating the reaction mixture under reduced pressure was purified by silica gel chromatography (3% methanol/chloroform→3% methanol, 3% tertbutylamine/chloroform), whereby the title compound (21 mg, 41%) was obtained as an oil.

Provenance & Evidence