Trifluoroacetic acid → HCID 23114565, compound

Participants

Reaction Steps

In methylene chloride (1.5 ml) was dissolved tert-butyl [4-[5-chloro-4-[(4-chlorophenylsulfonyl)-(2,5-difluorophenyl)methyl]pyridine-2-yl]morpholine-2-yl]methylcarbamate (30 mg, 0.05 mmol). After addition of anisole (30 μl) and trifluoroacetic acid (150 μl) at room temperature, the mixture was stirred for 1 hour. The residue obtained by concentrating the reaction mixture under reduced pressure was purified by silica gel chromatography (3% methanol/chloroform→3% methanol, 3% tert-butylamine/chloroform), whereby the title compound (17 mg, 67%) was obtained as an oil.

Provenance & Evidence