Hydrochloric Acid → HCID 68514257, compound

Participants

Reaction Steps

Dissolve the product of Example 1 (6.4 g, 12.1 mmol) in a mixture of ethyl acetate, dichloromethane, and methanol (300 mL; 2.5:2.5:1). Cool the resulting solution in an ice bath and treat with 2M HCl in diethyl ether (9.1 mL, 18.2 mmol). Concentrate the solution in vacuo and dry at 50° C. (<2 mm of Hg) for 18 hours to give 6.6 grams of the title compound (96%):mass spectrum (ion spray): m/z=532.3 (M+H—HCl).

Provenance & Evidence