HCID 11692407, compound → HCID 68514413, compound

Participants

Reaction Steps

Dissolve the compound of Example 74 (200 mg, 0.37 mmol) in THF (30 mL). Add lithium aluminum hydride (LAH, 70.3 mg). Quench with ice and water. Acidify with 1M aqueous HCl and make the solution slightly basic with aqueous NaHCO3. Extract with 25% i-PrOH in CHCl3. Purify the crude product using an SCX column eluting with 2M NH3/MeOH to afford 185 mg of the title compound (92%) LCMS: m/z=546 (M+H)+

Provenance & Evidence