Pyridinium chloride → HCID 11519653, compound

Participants

Reaction Conditions

Reaction Steps

Add pyridine hydrochloride (4 g) to the compound of Example 77 (110 mg, 0.21 mmol). Purge with nitrogen, cap the vessel and heat to 200° C. for 2 hours. Cool the reaction mixture and dilute with saturated aqueous NaHCO3. Extract with CH2Cl2, dry over Na2SO4, filter and concentrate. Purify the crude product by flash chromatography (0-10% MeOH/CH2Cl2). Dissolve the product in 1:1 CH3CN/1M aqueous HCl and lyophilize to afford 92 mg of the title compound (80%). LCMS: m/z=516 (M+H)+—HCl.

Provenance & Evidence