Sodium ethanethiolate → HCID 68521253, compound

Participants

Reaction Steps

In a round bottom flask place the compound of Example 104 (50 mg, 0.094 mmol), sodium ethanethiolate (88 mg, 1.05 mmol) and dimethylformamide (4 mL) in a round bottom flask, at room temperature. Place the reaction in a 95° C. oil bath and stir it for 4 hours, then cool it to ambient temperature. Quench the room temperature mixture with brine and extract it into ethyl acetate. Wash the combined extracts with brine; then dry (sodium sulfate) and concentrate them in vacuo. Purify the crude material on a Chromatotron (silica gel; 5%-12% MeOH gradient in CH2Cl2) to give 7 mg of the title Compound (14%). MS (IS+) m/e 520 (M+1).

Provenance & Evidence