Dichloromethane → HCID 15982710, compound

Participants

Reaction Conditions

Reaction Steps

The hydroxamate 48 (0.9 g) was dissolved in CH2Cl2 (25 mL) and cooled to 0-5° C. Hydrogen chloride gas was bubbled through this solution for 20 min. The bubbling was discontinued and the reaction mixture was stirred at room temperature for 1 h. The excess HCl was degassed and the CH2Cl2 was removed. The residual solid was triturated with EtOAc (2×30 mL), decanted, and dried to yield the desired compound 49 as a white amorphous solid (0.68 g, 88%). 1H NMR (DMSO-d6): 10.45 (s, 1H), 7.61 (d, J=8.4 Hz, 2H), 7.57 (d, J=8.0 Hz, 2H), 7.29 (d, J=8.4 Hz, 2H), 4.58 (m, 1H), 3.09 (dd, J=14.0 and 8.4 Hz, 1H), 3.01 (dd, J=14.0 and 7.2 Hz, 1H), 2.84 (t, J=6.8 Hz, 2H), 2.81 (s, 3H), 2.71 (s, 3H), 2.29 (t, J=7.2 Hz, 2H). LCMS (m/e): Obsd. [MH]+ 356, Calcd. 355.4

Provenance & Evidence