反应详情

To a solution of tert-butyl 2-[[[2-[5-chloro-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-3-yl]-5-fluoro-pyrimidin-4-yl]amino]methyl]-4,4-difluoro-piperidine-1-carboxylate, 13j, (0.23 g, 0.35 mmol) in methanol (4 mL) was added sodium methanolate (4 mL of 25% w/v, 18.51 mmol). The reaction mixture was allowed to stir at room temperature for 15 minutes. All volatiles were removed at reduced pressure and the residue was quenched with water. EtOAc was added and the layers were separated. The organic phase was washed with brine, dried (MgSO4), filtered and evaporated to dryness. The crude residue was pure enough to be used without further purification.

1. customAll volatiles were removed at reduced pressure
2. customthe residue was quenched with water
3. additionEtOAc was added
4. customthe layers were separated
5. washThe organic phase was washed with brine
6. dry with materialdried (MgSO4)
7. filtrationfiltered
8. customevaporated to dryness
9. customto be used without further purification