HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propargyl bromide → HCID 22048511, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propargyl bromide | HCID 7842 | — |
| Reactant | HCID 22048520 | HCID 22048520 | — |
| Reactant | Potassium butoxide | HCID 23699084 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 22048511 | HCID 22048511 | 62.8% |
Reaction Steps
The product from step 1 (1 g) was reacted with propargyl bromide (0.95 g) in the presence of potassium butoxide (0.53 g), tetrabutylammonium iodide (0.16 g) and 18C-6 crown ether (0.05 g), in solution in DMA (100 ml, 10° C. to ambient temperature). 3-cyano-4-chloro-6-propargyloxy-7-methoxyquinoline (0.73 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402583B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-f689e6296c9d46f2a3fafe17b3d9d3d2 |
| Source note | uspto-grants-2008_07 |