HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-(4-(2-Methoxyphenoxy)-anilino)-3-cyano-6-methoxy-7-glycidyloxy quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Oxiranemethanol, 4-methylbenzenesulfonate, (S)- | HCID 153296 | — |
| Reactant | 4-(4-(2-Methoxyphenoxy)-anilino)-3-cyano-6-methoxy-7-hydroxyquinoline | HCID 135819831 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-(4-(2-Methoxyphenoxy)-anilino)-3-cyano-6-methoxy-7-glycidyloxy quinoline | HCID 22048519 | — |
Reaction Steps
A solution of 4-(4-(2-methoxyphenoxy)-anilino)-3-cyano-6-methoxy-7-hydroxyquinoline (3.6 g, 8.0 mmole), prepared as described in Example 18 step 2, in DMSO (40 ml) was reacted with (2S)-(+)-glycidyl tosylate (2.3 g, 10 mmole) in the presence of potassium carbonate (2.8 g, 20 mmole) at room temperature for 18 hours. 4-(4-(2-methoxyphenoxy)-anilino)-3-cyano-6-methoxy-7-glycidyloxy quinoline was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402583B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-b3b90d258e0b4e4c9831466cf8f5d109 |
| Source note | uspto-grants-2008_07 |