Sodium Hydroxide → HCID 66966647, compound

HRID 749101Notes

Reaction equation

HRID 749101 reaction equation
[OH-].[Na+].C[O:4][C:5]([CH2:7][C:8]1[C:17]2[CH2:16][CH2:15][CH2:14][CH2:13][C:12]=2[C:11](=[O:18])[NH:10][N:9]=1)=[O:6]>CO>[C:5]([CH2:7][C:8]1[C:17]2[CH2:16][CH2:15][CH2:14][CH2:13][C:12]=2[C:11](=[O:18])[NH:10][N:9]=1)([OH:6])=[O:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66965872HCID 66965872, compound

Product 1

HCID 66966647HCID 66966647, compoundYield 80.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5N sodium hydroxide solution (1.72 mL) was added dropwise to a suspension of the compound prepared in Example 15 (635 mg) in methanol (10.0 mL) in ice bath and the mixture was stirred at room temperature for 3 hours. The reaction mixture was concentrate. 2N hydrochloric acid was added to the residue, which was adjusted to pH 2. The deposited crystal was collected by filtration. It was washed with hexane and dried under reduced pressure to give the title compound (478 mg) having the following physical data.

Workup

  1. concentrationThe reaction mixture was concentrate
  2. addition2N hydrochloric acid was added to the residue, which
  3. filtrationThe deposited crystal was collected by filtration
  4. washIt was washed with hexane
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-cb5a89b3466a496da28dff4f3bf8344f
Source dataset
uspto-grants-2008_07
Patent number
US07402580B2

Reaction notes

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